Vancomycin and ceftazidime bioactivities persist for at least 2 weeks in the lumen in ports: simplifying treatment of port-associated bloodstream infections by using the antibiotic lock technique.

نویسندگان

  • Y Haimi-Cohen
  • N Husain
  • J Meenan
  • G Karayalcin
  • M Lehrer
  • L G Rubin
چکیده

The residual antibiotic concentration of vancomycin (2 mg/ml)- or ceftazidime (2 mg/ml)-heparin solutions instilled in ports in pediatric hematology-oncology patients 1 to 34 days earlier was measured. Antibiotic concentrations of > or = 100 microg of either antibiotic per ml persisted for at least 21 days. For treatment of lumenal port infections, antibiotic-heparin dwell times of > or = 2 weeks may be appropriate.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 45 5  شماره 

صفحات  -

تاریخ انتشار 2001